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Depresie

Tristețe persistentă, lipsa energiei și a motivației.

106 articole
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StudiuDepresieÎncredere bună19.06.2026

Real-world Effectiveness of SAINT® (Accelerated Theta-Burst Stimulation) for Treatment-Resistant Depression in Diverse Clinical Settings

This open-label multicenter study evaluated SAINT®, a functional connectivity-guided form of intermittent theta-burst stimulation, in 101 adults with major depressive disorder who had not responded adequately to antidepressants. Treatment involved a 5-day protocol with 68.3% achieving significant improvement and 89.1% showing meaningful clinical benefit, with consistent results across sites and baseline severity levels.

StudiuDepresieÎncredere bună18.06.2026

Short-term ketamine use in bipolar depression: a review of the evidence for acute treatment management

This narrative review examines esketamine (ketamine's enantiomer) as a rapid-acting treatment option for bipolar depression, which carries high risks of suicidality and treatment resistance. Preliminary research suggests esketamine may be safe and effective as an add-on therapy with potential benefits for suicidal ideation, anhedonia, and anxiety, though evidence specific to bipolar disorder is less comprehensive than for unipolar depression.

StudiuDepresieÎncredere bună18.06.2026

A Review on Linking Stress, Depression, and Insulin Resistance via Low-Grade Chronic Inflammation

This review examines the bidirectional relationship between metabolic syndrome and depression, focusing on chronic low-grade inflammation and insulin resistance as connecting mechanisms. It evaluates evidence-based treatments including antidepressants, anti-inflammatory medications, and lifestyle modifications (exercise, diet, sleep) as approaches to address depression through metabolic and inflammatory pathways.

StudiuDepresieÎncredere bună18.06.2026

BDNF in Major Depression: Neurobiological Mechanisms and Therapeutic Implications

This review examines brain-derived neurotrophic factor (BDNF) and its involvement in major depressive disorder, focusing on its relationship with serotonergic dysfunction, HPA axis dysregulation, and oxidative stress. The authors discuss how decreased BDNF levels correlate with depressive symptoms and neuronal damage, and how antidepressant treatment can restore BDNF signaling pathways.

StudiuDepresieÎncredere bună18.06.2026

Algorithm-Guided Pharmacological Treatment for Major Depressive Disorder in China: Clinical Predictors and Outcomes

This study examined 987 Chinese MDD patients to identify clinical predictors of antidepressant response and compare algorithm-guided treatment (AGT) with standard care. Eight clinical traits including anxious characteristics predicted treatment resistance, while autonomic symptoms predicted better response; AGT showed longer symptom remission time than usual treatment, though not statistically significant.

StudiuDepresieÎncredere bună18.06.2026

The 'Discontinuity Hypothesis' of Depression in Later Life: Clinical and Research Implications

This narrative review challenges the assumption that depressed mood exists on a continuum with depressive disorders, proposing instead that in older adults, depressed mood may be an aging-related consequence of physical illness in people resilient to actual depressive disorders. The authors argue that differences in course, poor screening predictive value, and inconsistent dose-response relationships support reconceptualizing depression in later life, with implications for pharmacological treatment efficacy.

StudiuDepresieÎncredere bună18.06.2026

Digital Biomarkers in Major Depressive Disorder and Treatment-Resistant Depression: A Narrative Review

This narrative review examines digital biomarkers and wearable technologies used to predict diagnostic status, assess symptom severity, identify treatment response, and monitor real-world outcomes in major depressive disorder (MDD) and treatment-resistant depression (TRD). The analysis of 12 peer-reviewed studies from 2013-2023 shows that physiological, activity/sleep, and subjective data collected via wearable devices show promise in improving depression management given the current low remission rates.

StudiuDepresieÎncredere bună18.06.2026

Preventing recurrence of postpartum depression by regulating sleep

This review examines medication and psychotherapy approaches for preventing postpartum depression in women with prior mood disorders, finding contradictory results from prophylactic drug studies. The authors propose that addressing sleep loss and insomnia—common early symptoms in perinatal psychiatric disorders—may be a more effective prevention strategy than traditional antidepressant-only approaches.

StudiuDepresieÎncredere bună18.06.2026

Cariprazine augmentation in treatment-resistant depression: A case-series of patients failing previous atypical antipsychotic augmentation

This case-series documents ten patients with treatment-resistant unipolar depression who had failed conventional antidepressant monotherapy and initial augmentation with standard atypical antipsychotics (aripiprazole, risperidone, or brexpiprazole). The study explores switching to cariprazine as a second-line augmentation strategy, with seven of ten patients showing clinical improvement.

StudiuDepresieÎncredere bună18.06.2026

Sertraline Treatment of Depression with Psychotic Features in an Adolescent with Dystonia

A case report of a 17-year-old female with dystonia whose depressive and psychotic symptoms persisted despite dopaminergic treatment but improved after sertraline addition without motor symptom worsening. The authors emphasize that psychiatric disorders may be intrinsic to dystonia's neurobiology rather than purely secondary, highlighting the importance of early detection and integrated treatment approaches.

StudiuDepresieÎncredere bună17.06.2026

Neurofilament light chain plasma levels in major depressive disorder: a brief research report

This study measured plasma neurofilament light chain (NfL) levels using advanced SIMOA technology in 15 major depressive disorder patients and 15 healthy controls to investigate whether NfL is altered in depression. The researchers found no significant difference in NfL plasma levels between groups and no correlation with depression severity measures, though age showed positive correlation with NfL in both groups.

StudiuDepresieÎncredere bună17.06.2026

Targeting Divergent Pathways in the Nutritional Management of Depression

This narrative review examines nutritional approaches to depression management, focusing on nutrients with substantial scientific evidence including vitamin D, B vitamins, and omega-3 fatty acids. The paper synthesizes epidemiological data, mechanistic explanations, and intervention studies while positioning nutrition as a complementary strategy alongside pharmaceutical treatment.

StudiuDepresieÎncredere bună17.06.2026

Analgesics and Adjuvant Medications: Effects on Psychiatric Comorbidities in Complex Regional Pain Syndrome

This observational study of 1,029 CRPS patients examined how different pain medications affect psychiatric outcomes, finding no significant differences between opioid and non-opioid analgesics for depression or anxiety, but showing anticonvulsants were associated with higher risk of psychiatric comorbidities compared to antidepressants. The results suggest antidepressants may offer greater psychiatric benefits for CRPS patients while highlighting the need for individualized treatment planning.

StudiuDepresieÎncredere bună17.06.2026

Effects of Light Therapy in the Anxious-Depressive Clinic

Light therapy is an established therapeutic intervention studied for treating depression and anxiety symptoms in clinical settings. Research supports its use particularly for seasonal mood disorders, though effectiveness varies across conditions and patient populations.