Chronic Stress in a Rat Model of Depression Disturbs the Glutamine-Glutamate-GABA Cycle in the Striatum, Hippocampus, and Cerebellum

This study investigates how chronic stress affects neurotransmitter metabolism in specific brain regions of depressed rats, focusing on disruptions to the glutamine-glutamate-GABA cycle. The research contributes to understanding the neurobiological mechanisms underlying depression and potential therapeutic targets.