BDNF in Major Depression: Neurobiological Mechanisms and Therapeutic Implications

This review examines brain-derived neurotrophic factor (BDNF) and its involvement in major depressive disorder, focusing on its relationship with serotonergic dysfunction, HPA axis dysregulation, and oxidative stress. The authors discuss how decreased BDNF levels correlate with depressive symptoms and neuronal damage, and how antidepressant treatment can restore BDNF signaling pathways.