Algorithm-Guided Pharmacological Treatment for Major Depressive Disorder in China: Clinical Predictors and Outcomes

This study examined 987 Chinese MDD patients to identify clinical predictors of antidepressant response and compare algorithm-guided treatment (AGT) with standard care. Eight clinical traits including anxious characteristics predicted treatment resistance, while autonomic symptoms predicted better response; AGT showed longer symptom remission time than usual treatment, though not statistically significant.