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Baseline Brain Volumes Predict Cognitive Decline More Robustly Than Atrophy Rates: Evidence for Brain Reserve

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Stage-specific hippocampal network degeneration links amyloid-β pathology to cognitive decline in mild cognitive impairment: right subiculum as structural biomarker

This study examined 465 participants across the Alzheimer's disease continuum to understand how amyloid-β pathology causes cognitive decline through hippocampal subfield atrophy. Progressive hippocampal degeneration at the mild cognitive impairment stage mediated amyloid-related cognitive decline in memory, global cognition, and attention, with the right subiculum identified as a key structural biomarker.

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Validation of proper name recall decline with pTau217 as an early cognitive marker in at-risk cognitively unimpaired adults

This study validates that proper name recall from the Logical Memory task is sensitive to blood-based pTau217 levels, with participants showing higher pTau217 concentrating displaying steeper cognitive decline. APOE ε4 allele carriers with elevated pTau217 showed greater longitudinal decline, suggesting proper name recall may be a useful marker for detecting early cognitive changes in preclinical Alzheimer's disease.

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Persistent Functional Impairment as a Preclinical Marker of Alzheimer's Disease: Advancing Dementia Risk Prediction

Research shows that persistent (not temporary) functional decline in cognitively normal older adults is a strong predictor of future cognitive decline and dementia development. The study proposes using functional trajectory monitoring as a practical, scalable biomarker for early dementia detection that complements cognitive testing and biomarkers.

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Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum

This review examines diffusion magnetic resonance imaging (dMRI) findings across multiple dementia types, including Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, and primary progressive aphasia, identifying both shared and disease-specific patterns of white matter degeneration. Advanced dMRI methods such as NODDI and free-water imaging reveal microstructural alterations in specific brain tracts that correlate with each syndrome's clinical features and may improve early diagnosis and disease monitoring.