Stage-specific hippocampal network degeneration links amyloid-β pathology to cognitive decline in mild cognitive impairment: right subiculum as structural biomarker

This study examined 465 participants across the Alzheimer's disease continuum to understand how amyloid-β pathology causes cognitive decline through hippocampal subfield atrophy. Progressive hippocampal degeneration at the mild cognitive impairment stage mediated amyloid-related cognitive decline in memory, global cognition, and attention, with the right subiculum identified as a key structural biomarker.