Validation of proper name recall decline with pTau217 as an early cognitive marker in at-risk cognitively unimpaired adults

This study validates that proper name recall from the Logical Memory task is sensitive to blood-based pTau217 levels, with participants showing higher pTau217 concentrating displaying steeper cognitive decline. APOE ε4 allele carriers with elevated pTau217 showed greater longitudinal decline, suggesting proper name recall may be a useful marker for detecting early cognitive changes in preclinical Alzheimer's disease.