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StudiuSindrom DownÎncredere bună29.06.2026

Emerging adults' emotional responses toward siblings with Down syndrome: The role of support, optimism, and sense of coherence

This study examined 292 emerging adult siblings (ages 18-27) of individuals with Down syndrome to identify factors influencing their emotional responses toward their affected sibling. Higher social support and optimism predicted more positive emotions, while stronger sense of coherence was associated with fewer negative emotions; sibling functionality and religious affiliation also moderated these relationships.

StudiuSindrom DownÎncredere înaltă27.06.2026

Extracellular Matrix Defects Destabilize Apical Cytoarchitecture and Mechanical Properties During Early Down Syndrome Neurodevelopment

This study uses cerebellar organoids and neural cultures to show that trisomy 21 causes extracellular matrix alterations that impair apical progenitor cell organization and reduce RAB11+ endosomes, leading to disrupted neural stem cell integrity. Supplementing cultures with extracellular matrix partially rescues these defects, demonstrating a functional role for ECM in maintaining proper apical organization during Down syndrome brain development.

StudiuSindrom DownÎncredere bună27.06.2026

Vaccine Response Assessment in Children With Down Syndrome: A Case Report of Improved Outcomes With Enhanced Immunization Strategy

Children with Down syndrome may have altered immune responses to routine vaccinations despite complete immunization records, resulting in inadequate protection against infections. This case describes a 5-year-old with Down syndrome who experienced recurrent respiratory infections despite adherence to standard vaccination schedules; additional pneumococcal vaccination led to notable clinical improvement, suggesting the value of immunology consultation and individualized vaccine response monitoring in this population.