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A case report describes a patient with intensified hypnic jerks (involuntary sleep-wake transition movements) that contributed to major depressive disorder development. While escitalopram improved depression, it paradoxically worsened jerks; clonazepam effectively reduced both symptoms and stabilized the patient's condition.
This study examined 987 Chinese MDD patients to identify clinical predictors of antidepressant response and compare algorithm-guided treatment (AGT) with standard care. Eight clinical traits including anxious characteristics predicted treatment resistance, while autonomic symptoms predicted better response; AGT showed longer symptom remission time than usual treatment, though not statistically significant.
This narrative review challenges the assumption that depressed mood exists on a continuum with depressive disorders, proposing instead that in older adults, depressed mood may be an aging-related consequence of physical illness in people resilient to actual depressive disorders. The authors argue that differences in course, poor screening predictive value, and inconsistent dose-response relationships support reconceptualizing depression in later life, with implications for pharmacological treatment efficacy.
This narrative review examines digital biomarkers and wearable technologies used to predict diagnostic status, assess symptom severity, identify treatment response, and monitor real-world outcomes in major depressive disorder (MDD) and treatment-resistant depression (TRD). The analysis of 12 peer-reviewed studies from 2013-2023 shows that physiological, activity/sleep, and subjective data collected via wearable devices show promise in improving depression management given the current low remission rates.
This review examines medication and psychotherapy approaches for preventing postpartum depression in women with prior mood disorders, finding contradictory results from prophylactic drug studies. The authors propose that addressing sleep loss and insomnia—common early symptoms in perinatal psychiatric disorders—may be a more effective prevention strategy than traditional antidepressant-only approaches.