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This theoretical framework proposes that MS pathogenesis involves TNFα-induced breakdown of ceramide-based membrane stabilizers (sphingomyelin and galactosylceramide), facilitating immune cell infiltration across the blood-brain barrier and myelin damage. The mechanism explains disease relapsing-remitting patterns and aligns with current B-cell targeted therapeutic approaches.
This is a corrigendum (correction notice) for a peer-reviewed study investigating biomarkers that predict treatment response to ocrelizumab in patients with relapsing-remitting multiple sclerosis. The notice addresses corrections to the original published article.
This retrospective study examined 249 pediatric MS patients in Kuwait, finding a predominantly female cohort (70.3%) with mean onset age 15 years, most presenting with brainstem/cerebellar symptoms. Most patients remained in relapsing-remitting phenotype during follow-up, though disease breakthrough occurred in 36.1% of cases, prompting escalation or switching of disease-modifying therapies.
This cross-sectional study examined lipid profiles and lipoprotein particle characteristics in 203 healthy controls, 221 patients with relapsing-remitting MS, and 126 with progressive MS, using advanced NMR profiling and immunoassay methods. Results showed similar dyslipidemia frequency across groups but progressive MS exhibited altered triglyceride-rich and LDL particle concentrations, with lower disability scores associated with higher HDL particle levels.
This research investigates the relationship between hippocampal antibodies and cognitive impairment in multiple sclerosis patients. The study examines potential autoimmune mechanisms underlying cognitive dysfunction, a common but often under-recognized MS symptom.