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StudiuAutism + ADHDÎncredere bună20.06.2026

Comorbidity of Autism Spectrum Disorder and Personality Disorders with Eating Disorders, PTSD, and Somatic Symptom Disorder: Clinical Challenges and Treatment Implications

This clinical review examines the prevalence and mechanisms underlying comorbidity between autism spectrum disorder, eating disorders, and PTSD when occurring alongside personality disorders, noting that such combinations typically increase symptom severity and suicide risk. Evidence-based treatments exist but novel approaches are needed, with future research prioritizing ASD-personality disorder trajectories and trauma-informed interventions addressing emotion dysregulation and patient engagement.

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Dynamic limbic-executive decoupling underpins the reciprocal link between drug-resistant epilepsy and depression in temporal lobe epilepsy

This neuroimaging study of 82 temporal lobe epilepsy patients and 50 controls examined whether disrupted functional connectivity between limbic and executive brain networks explains the bidirectional relationship between drug-resistant seizures and depression. Using resting-state fMRI combined with receptor mapping and gene expression analysis, the researchers identified specific patterns of brain network integration that statistically link drug resistance severity and depression symptoms.

StudiuAutism + ADHDÎncredere înaltă19.06.2026

Pupillary Dilation in Adolescent with Psychogenic Non-epileptic Seizures: Clinical Case Report

A 16-year-old female with trauma history and mood disorder presented with recurrent psychogenic non-epileptic seizures (PNES) during hospitalization, characterized by unresponsiveness, irregular movements, and sympathetic activation including pupillary dilation. Video-EEG monitoring ruled out epileptic activity, confirming PNES diagnosis; treatment with sertraline and behavioral strategies including mindfulness resulted in symptom reduction and improved psychiatric outcomes by discharge.

StudiuAutism + ADHDÎncredere înaltă19.06.2026

Atraumatic Bilateral Anterior Shoulder Dislocation With Bilateral Greater Tuberosity Fractures Accompanying Epilepsy Diagnosis: A Case Report

A 23-year-old woman presented with bilateral shoulder pain and dislocation with fractures following an unwitnessed seizure, with no external trauma involved. Surgical fixation via cannulated screws and plate osteosynthesis resulted in favorable outcomes, highlighting the importance of systematic orthopedic evaluation in post-seizure patients and the potential for severe musculoskeletal injury from seizure-induced muscle contractions.

StudiuAutism + ADHDÎncredere înaltă19.06.2026

Diagnostic and Prognostic Value of Epigenetic Markers in Neurological Diseases: A Narrative Review

This narrative review synthesizes current evidence on epigenetic modifications (DNA methylation, histone changes, and non-coding RNAs) as potential biomarkers for diagnosing and predicting outcomes in neurological diseases including neurodegenerative disorders, multiple sclerosis, and stroke. The authors identified 65 studies demonstrating that disease-associated epigenetic signatures can distinguish patients from controls and correlate with disease severity and clinical progression across multiple neurological conditions.