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This study investigates how impaired executive function and deficient decision-making processes relate to the development and progression of gambling disorder symptoms in individuals who engage in online sports betting. The research explores neuropsychological factors underlying problematic gambling behavior as a behavioral addiction.
This study analyzed genetic and social factors contributing to comorbid conditions in people with substance use disorders using data from 393,596 individuals. Polygenic scores for alcohol use, cannabis use, depression, and schizophrenia were significantly associated with time to subsequent diagnoses, while social determinants like low household income showed strong associations with lifetime SUD risk.
This study validated the Turkish translation of the SSBA, a screening tool assessing both substance-related and behavioral addictions across ten dimensions. The instrument demonstrated excellent internal consistency (α=0.94) and effectively distinguished between clinical and general populations, supporting its reliability for addiction assessment in clinical and research contexts.
This review examines mGluR2 (metabotropic glutamate receptor 2) as a promising molecular target for treating alcohol use disorder, which involves dysregulated glutamatergic neurotransmission. Preclinical evidence supports that mGluR2 agonists and positive allosteric modulators can reduce alcohol-seeking behaviors by restoring glutamatergic homeostasis.
This longitudinal study of 5,172 Finnish adults with gambling disorder found high co-occurrence with mood, anxiety, and substance use disorders, with bidirectional comorbidity patterns. Most psychiatric diagnoses preceded gambling disorder diagnosis by 112–2,697 days, with mood disorders more prominent in women and substance use disorders more common in men.