Polygenic Risk Factors for Comorbid Diagnoses in Individuals with Substance Use Disorders: A Phenome-Wide Survival Analysis

This study analyzed genetic and social factors contributing to comorbid conditions in people with substance use disorders using data from 393,596 individuals. Polygenic scores for alcohol use, cannabis use, depression, and schizophrenia were significantly associated with time to subsequent diagnoses, while social determinants like low household income showed strong associations with lifetime SUD risk.