Metabotropic Glutamate Receptors as Therapeutic Targets for Alcohol Use Disorder

This review examines mGluR2 (metabotropic glutamate receptor 2) as a promising molecular target for treating alcohol use disorder, which involves dysregulated glutamatergic neurotransmission. Preclinical evidence supports that mGluR2 agonists and positive allosteric modulators can reduce alcohol-seeking behaviors by restoring glutamatergic homeostasis.