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StudiuParkinsonÎncredere bună19.06.2026

Region-based morphometry in Parkinson's disease patients with GBA mutation and its predictive role for cognition after STN-DBS

This study used advanced brain imaging (region-based morphometry) to identify structural brain differences in Parkinson's disease patients carrying GBA mutations who underwent deep brain stimulation treatment. Researchers found significant atrophy in specific brain regions and tracked cognitive and motor outcomes, finding no significant cognitive decline one year after surgery despite baseline anatomical differences.

StudiuParkinsonÎncredere bună19.06.2026

The impact of cardiovascular disease on Parkinson's disease: Findings from the PPMI study

A cross-sectional analysis of 1,109 participants from the Parkinson's Progression Markers Initiative found that cardiovascular disease history was not associated with Parkinson's disease occurrence or progression in cognitive and autonomic domains, but was linked to higher risk of motor complications. The study used validated rating scales (MDS-UPDRS, SCOPA-AUT, MoCA) with a mean follow-up of 4.84 years in predominantly early-stage PD patients.

StudiuParkinsonÎncredere înaltă19.06.2026

Five-year cardiovascular and fall risk in Parkinson's disease patients with orthostatic hypotension: A nationwide cohort study

This large cohort study of 111,368 Parkinson's disease patients found that orthostatic hypotension independently increased the 5-year risk of falls by 35% and cumulative fall counts by 22%, but was not associated with major vascular events. Among patients with orthostatic hypotension, pharmacotherapy paradoxically correlated with higher fall risk, suggesting complex clinical trade-offs in managing this autonomic feature.

StudiuParkinsonÎncredere bună19.06.2026

Domain-specific severity profiles in a large Turkish Parkinson's disease cohort using MDS-UPDRS cut-offs

This multicenter cross-sectional study of 1,181 Turkish PD patients used validated MDS-UPDRS severity cut-offs to classify symptom burden across motor, non-motor, and functional domains. The analysis revealed that patient-reported non-motor and daily-living impairments were predominantly mild, while motor examination scores showed greater moderate-to-severe severity, with disease duration being the strongest clinical correlate.

StudiuParkinsonÎncredere bună19.06.2026

Comparative Analysis of Burnout Reduction Following Telerehabilitation in Neurological Patient Groups

This retrospective study evaluated burnout levels in 211 adults with various neurological conditions (hemiplegia/paraplegia/tetraplegia, Parkinson's disease, aphasia) before and after a standardized 6-week telerehabilitation program using validated outcome measures. Burnout scores significantly decreased across all diagnostic groups, with notably greater improvements in Parkinson's disease patients, and larger reductions observed in male participants and those aged 65 years or older.