Domain-specific severity profiles in a large Turkish Parkinson's disease cohort using MDS-UPDRS cut-offs

This multicenter cross-sectional study of 1,181 Turkish PD patients used validated MDS-UPDRS severity cut-offs to classify symptom burden across motor, non-motor, and functional domains. The analysis revealed that patient-reported non-motor and daily-living impairments were predominantly mild, while motor examination scores showed greater moderate-to-severe severity, with disease duration being the strongest clinical correlate.