Region-based morphometry in Parkinson's disease patients with GBA mutation and its predictive role for cognition after STN-DBS

This study used advanced brain imaging (region-based morphometry) to identify structural brain differences in Parkinson's disease patients carrying GBA mutations who underwent deep brain stimulation treatment. Researchers found significant atrophy in specific brain regions and tracked cognitive and motor outcomes, finding no significant cognitive decline one year after surgery despite baseline anatomical differences.