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StudiuScleroză multiplăÎncredere bună20.06.2026

Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis

This clinical study of 149 MS patients found that 16% developed polyneuropathy (PNP), with highest prevalence (35.7%) in secondary progressive MS, and identified male gender and higher neuropathy scores as risk factors. Nerve conduction studies confirmed demyelinating characteristics of PNP in MS, suggesting peripheral nervous system involvement despite MS primarily affecting the central nervous system.

StudiuScleroză multiplăÎncredere înaltă20.06.2026

Over-Reliance on Prior Expectations in Relapsing-Remitting Multiple Sclerosis: A Bayesian Analysis of Cognitive Dysfunction

This case-control study applied Bayesian computational modeling to examine how patients with relapsing-remitting MS process temporal information, revealing increased bias toward prior expectations over sensory information compared to healthy controls. The findings suggest that greater sensory measurement noise in MS patients drives this cognitive dysfunction, and unlike healthy aging, age-related changes in reliance on prior expectations are absent in MS patients.

StudiuScleroză multiplăÎncredere bună20.06.2026

Hyperprolactinemia as a manifestation of multiple sclerosis relapse

A 31-year-old woman with MS presented with galactorrhea and elevated prolactin levels without pituitary pathology; both resolved following intravenous methylprednisolone treatment. This case demonstrates that MS-related hyperprolactinemia may not require dopaminergic intervention if the underlying cause is inflammatory demyelination rather than pituitary adenoma.

StudiuScleroză multiplăÎncredere bună20.06.2026

Cardiogenic shock after ocrelizumab infusion in relapsing-remitting multiple sclerosis

A 42-year-old man with relapsing-remitting MS developed severe reversible left ventricular dysfunction 24-36 hours after ocrelizumab infusion, with comprehensive cardiac investigation excluding ischemic or infectious causes. This case raises awareness of a potential rare cardiotoxic effect of ocrelizumab and underscores the need for cardiac monitoring in MS patients receiving this therapy.

StudiuScleroză multiplăÎncredere bună20.06.2026

Autologous Stem Cell Transplantation for Multiple Sclerosis: Current Evidence and Clinical Applications

This review examines autologous hematopoietic stem cell transplantation (AHSCT) as an emerging therapeutic option for patients with relapsing-remitting MS who are resistant to disease-modifying therapies, demonstrating sustained remission and lower relapse rates compared to conventional treatments. While AHSCT shows promise in preventing progression and improving neurological outcomes, results are mixed in progressive MS cases, and further research is needed to identify optimal patient selection and transplant protocols.