Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis

This clinical study of 149 MS patients found that 16% developed polyneuropathy (PNP), with highest prevalence (35.7%) in secondary progressive MS, and identified male gender and higher neuropathy scores as risk factors. Nerve conduction studies confirmed demyelinating characteristics of PNP in MS, suggesting peripheral nervous system involvement despite MS primarily affecting the central nervous system.