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StudiuScleroză multiplăÎncredere bună20.06.2026

Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: UK Experience and Clinical Outcomes

This commentary discusses a UK study of 364 multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (aHSCT), showing positive responses across all MS types, with particularly high response rates in relapsing-remitting forms. The authors argue that aHSCT represents a powerful, effective, and safer therapeutic option for MS patients compared to conventional disease-modifying treatments.

StudiuScleroză multiplăÎncredere bună20.06.2026

Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis

This clinical study of 149 MS patients found that 16% developed polyneuropathy (PNP), with highest prevalence (35.7%) in secondary progressive MS, and identified male gender and higher neuropathy scores as risk factors. Nerve conduction studies confirmed demyelinating characteristics of PNP in MS, suggesting peripheral nervous system involvement despite MS primarily affecting the central nervous system.

StudiuScleroză multiplăÎncredere înaltă20.06.2026

Over-Reliance on Prior Expectations in Relapsing-Remitting Multiple Sclerosis: A Bayesian Analysis of Cognitive Dysfunction

This case-control study applied Bayesian computational modeling to examine how patients with relapsing-remitting MS process temporal information, revealing increased bias toward prior expectations over sensory information compared to healthy controls. The findings suggest that greater sensory measurement noise in MS patients drives this cognitive dysfunction, and unlike healthy aging, age-related changes in reliance on prior expectations are absent in MS patients.

StudiuScleroză multiplăÎncredere bună20.06.2026

Autologous Stem Cell Transplantation for Multiple Sclerosis: Current Evidence and Clinical Applications

This review examines autologous hematopoietic stem cell transplantation (AHSCT) as an emerging therapeutic option for patients with relapsing-remitting MS who are resistant to disease-modifying therapies, demonstrating sustained remission and lower relapse rates compared to conventional treatments. While AHSCT shows promise in preventing progression and improving neurological outcomes, results are mixed in progressive MS cases, and further research is needed to identify optimal patient selection and transplant protocols.