Ai întrebări despre autism, ADHD, anxietate sau depresie? Găsești ghiduri clare, verificate de specialiști. Acum, acces gratuit.
This genome-wide association study investigates the distinct genetic factors underlying specific cognitive domains (memory, language, executive function) affected in Alzheimer's disease. The research identifies domain-specific genetic architecture, suggesting that different cognitive impairments in AD may have partially distinct genetic underpinnings.
This research examines how oral microbiome dysbiosis contributes to Alzheimer's disease through TLR/NLR immune signaling pathways that trigger systemic and neuroinflammation. The oral microbiome composition is proposed as a potential biomarker for early diagnosis and screening of cognitive decline, with discussion of targeted therapeutic approaches like TLR/NLR inhibitors.
This clinical study analyzed 184 Alzheimer's disease patients stratified by sex to examine relationships between sleep disturbances, neuropsychiatric symptoms, and cognitive progression. Patients with disturbed sleep showed worse cognitive performance and higher rates of depression, anxiety, and behavioral problems, with sex-specific patterns: women exhibited more disinhibition and depression while men showed greater cognitive decline and higher caregiver burden.
This 7-year retrospective study of 791 memory clinic patients examined cognitive decline patterns across three neurocognitive disorder etiologies: Alzheimer's disease, vascular encephalopathy, and mixed presentations. Alzheimer's disease showed steeper annual cognitive decline (~2.0 MMSE points/year) compared to vascular disease, while early diagnosis and higher baseline cognitive scores were associated with slower decline.
This case-control study of 240 participants examined how MTHFR gene variants (C677T and A1298C) influence Alzheimer's disease risk through disruptions in one-carbon metabolism and increased homocysteine levels. Researchers found these polymorphisms significantly associated with AD risk and correlated with metabolic alterations, reduced cognitive function, and white matter changes on MRI.