TLRs and NLRs in Oral Microbiome Involvement in Alzheimer's Disease Pathogenesis

This research examines how oral microbiome dysbiosis contributes to Alzheimer's disease through TLR/NLR immune signaling pathways that trigger systemic and neuroinflammation. The oral microbiome composition is proposed as a potential biomarker for early diagnosis and screening of cognitive decline, with discussion of targeted therapeutic approaches like TLR/NLR inhibitors.