MTHFR Gene Polymorphisms and Their Association with Metabolic Changes, Brain Imaging Findings, and Cognitive Decline in Alzheimer's Disease

This case-control study of 240 participants examined how MTHFR gene variants (C677T and A1298C) influence Alzheimer's disease risk through disruptions in one-carbon metabolism and increased homocysteine levels. Researchers found these polymorphisms significantly associated with AD risk and correlated with metabolic alterations, reduced cognitive function, and white matter changes on MRI.