Trajectories of cognitive decline in neurocognitive disorders: A seven-year retrospective cohort study

This 7-year retrospective study of 791 memory clinic patients examined cognitive decline patterns across three neurocognitive disorder etiologies: Alzheimer's disease, vascular encephalopathy, and mixed presentations. Alzheimer's disease showed steeper annual cognitive decline (~2.0 MMSE points/year) compared to vascular disease, while early diagnosis and higher baseline cognitive scores were associated with slower decline.