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Sănătate mintală și neurodezvoltare

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StudiuScleroză multiplăÎncredere înaltă20.06.2026

Adalimumab-Associated Transverse Myelitis Revealing Relapsing-Remitting Multiple Sclerosis in a Crohn's Disease Patient: A Case Report

A 40-year-old woman with Crohn's disease on adalimumab presented with acute transverse myelitis characterized by leg weakness and sensory loss. MRI and CSF analysis confirmed CNS demyelination, and combined with a retrospectively identified prior relapse, she was diagnosed with relapsing-remitting MS; discontinuation of adalimumab and corticosteroid treatment led to neurological improvement.

StudiuScleroză multiplăÎncredere bună20.06.2026

Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: UK Experience and Clinical Outcomes

This commentary discusses a UK study of 364 multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (aHSCT), showing positive responses across all MS types, with particularly high response rates in relapsing-remitting forms. The authors argue that aHSCT represents a powerful, effective, and safer therapeutic option for MS patients compared to conventional disease-modifying treatments.

StudiuScleroză multiplăÎncredere înaltă20.06.2026

Natalizumab for Multiple Sclerosis: A Systematic Review of Efficacy and Safety

This Cochrane systematic review evaluates natalizumab, a monoclonal antibody approved for highly active relapsing-remitting MS, by synthesizing randomized controlled trials comparing its effectiveness alone or combined with other treatments versus controls or other disease-modifying therapies. The review assesses outcomes including relapse rates, disability progression, adverse events, MRI lesion activity, quality of life, and treatment discontinuation through meta-analysis.

StudiuScleroză multiplăÎncredere bună20.06.2026

Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis

This clinical study of 149 MS patients found that 16% developed polyneuropathy (PNP), with highest prevalence (35.7%) in secondary progressive MS, and identified male gender and higher neuropathy scores as risk factors. Nerve conduction studies confirmed demyelinating characteristics of PNP in MS, suggesting peripheral nervous system involvement despite MS primarily affecting the central nervous system.