Natalizumab for Multiple Sclerosis: A Systematic Review of Efficacy and Safety

This Cochrane systematic review evaluates natalizumab, a monoclonal antibody approved for highly active relapsing-remitting MS, by synthesizing randomized controlled trials comparing its effectiveness alone or combined with other treatments versus controls or other disease-modifying therapies. The review assesses outcomes including relapse rates, disability progression, adverse events, MRI lesion activity, quality of life, and treatment discontinuation through meta-analysis.