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This retrospective study examined 249 pediatric MS patients in Kuwait, finding a predominantly female cohort (70.3%) with mean onset age 15 years, most presenting with brainstem/cerebellar symptoms. Most patients remained in relapsing-remitting phenotype during follow-up, though disease breakthrough occurred in 36.1% of cases, prompting escalation or switching of disease-modifying therapies.
This cross-sectional study examined lipid profiles and lipoprotein particle characteristics in 203 healthy controls, 221 patients with relapsing-remitting MS, and 126 with progressive MS, using advanced NMR profiling and immunoassay methods. Results showed similar dyslipidemia frequency across groups but progressive MS exhibited altered triglyceride-rich and LDL particle concentrations, with lower disability scores associated with higher HDL particle levels.
This research investigates the relationship between hippocampal antibodies and cognitive impairment in multiple sclerosis patients. The study examines potential autoimmune mechanisms underlying cognitive dysfunction, a common but often under-recognized MS symptom.
This study of 1542 MS patients and 700 controls found that people with MS have lower odds of seasonal allergies compared to unaffected controls, with variations by MS disease course. Genetic analysis revealed that MS-specific genetic risk factors (HLA-DRB1*15:01 and non-MHC genetic risk scores) are associated with differential susceptibility to allergic conditions in MS patients.
A 40-year-old woman with Crohn's disease on adalimumab presented with acute transverse myelitis characterized by leg weakness and sensory loss. MRI and CSF analysis confirmed CNS demyelination, and combined with a retrospectively identified prior relapse, she was diagnosed with relapsing-remitting MS; discontinuation of adalimumab and corticosteroid treatment led to neurological improvement.