Allergic phenotypes and asthma in multiple sclerosis: Epidemiologic and genetic relationships

This study of 1542 MS patients and 700 controls found that people with MS have lower odds of seasonal allergies compared to unaffected controls, with variations by MS disease course. Genetic analysis revealed that MS-specific genetic risk factors (HLA-DRB1*15:01 and non-MHC genetic risk scores) are associated with differential susceptibility to allergic conditions in MS patients.