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StudiuScleroză multiplăÎncredere bună20.06.2026

Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: UK Experience and Clinical Outcomes

This commentary discusses a UK study of 364 multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (aHSCT), showing positive responses across all MS types, with particularly high response rates in relapsing-remitting forms. The authors argue that aHSCT represents a powerful, effective, and safer therapeutic option for MS patients compared to conventional disease-modifying treatments.

StudiuScleroză multiplăÎncredere înaltă20.06.2026

Natalizumab for Multiple Sclerosis: A Systematic Review of Efficacy and Safety

This Cochrane systematic review evaluates natalizumab, a monoclonal antibody approved for highly active relapsing-remitting MS, by synthesizing randomized controlled trials comparing its effectiveness alone or combined with other treatments versus controls or other disease-modifying therapies. The review assesses outcomes including relapse rates, disability progression, adverse events, MRI lesion activity, quality of life, and treatment discontinuation through meta-analysis.

StudiuScleroză multiplăÎncredere bună20.06.2026

Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis

This clinical study of 149 MS patients found that 16% developed polyneuropathy (PNP), with highest prevalence (35.7%) in secondary progressive MS, and identified male gender and higher neuropathy scores as risk factors. Nerve conduction studies confirmed demyelinating characteristics of PNP in MS, suggesting peripheral nervous system involvement despite MS primarily affecting the central nervous system.

StudiuScleroză multiplăÎncredere înaltă20.06.2026

Over-Reliance on Prior Expectations in Relapsing-Remitting Multiple Sclerosis: A Bayesian Analysis of Cognitive Dysfunction

This case-control study applied Bayesian computational modeling to examine how patients with relapsing-remitting MS process temporal information, revealing increased bias toward prior expectations over sensory information compared to healthy controls. The findings suggest that greater sensory measurement noise in MS patients drives this cognitive dysfunction, and unlike healthy aging, age-related changes in reliance on prior expectations are absent in MS patients.