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Sănătate mintală și neurodezvoltare

Afecțiuni neurologice

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StudiuDemențeÎncredere înaltă21.06.2026

Neuropsychiatric Presentations of Common Dementia Syndromes: A Clinical Review for Primary Care

This review examines neuropsychiatric symptoms (NPS) across four major dementia syndromes—Alzheimer's disease, vascular dementia, Lewy body dementia, and frontotemporal dementia—highlighting that these symptoms often emerge early or even precede cognitive decline. The article provides clinical guidance for primary care teams to recognize prodromal neurodegenerative disease and initiate appropriate diagnostic workup, addressing gaps in dementia training among frontline practitioners.

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The Mediterranean Diet as a Potential Defense Against Alzheimer's Disease: A Comprehensive Review

Recent observational studies suggest the Mediterranean diet may be associated with reduced cognitive decline and lower Alzheimer's disease risk, possibly through vascular, metabolic, and anti-inflammatory mechanisms. However, causality has not been established, and large-scale randomized controlled trials are needed to confirm whether the diet can serve as a preventive strategy for dementia.

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Asymmetrical β-amyloid deposition patterns and cognitive decline in Alzheimer's disease: findings from the SILCODE study

This longitudinal study examined asymmetric distribution of β-amyloid plaques across the brain in 148 participants spanning normal cognition to Alzheimer's disease dementia. The research found that β-amyloid lateralization varies by disease stage and correlates with cognitive performance, suggesting potential utility as a neuroimaging biomarker for tracking disease progression.

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Hypertension and Cognitive Disorders: A Review of Associations and Therapeutic Implications

This review examines how hypertension contributes to major neurocognitive disorders including Alzheimer's disease, vascular dementia, and Lewy body dementia through vascular damage, inflammation, and blood-brain barrier disruption. While antihypertensive medications show promise in some studies, evidence remains inconsistent, highlighting the need for long-term prospective research to clarify treatment effectiveness and the bidirectional relationship between hypertension and cognitive decline.

StudiuDemențeÎncredere înaltă21.06.2026

Brain Metabolic Resilience in Alzheimer's Disease: A Predictor of Cognitive Decline and Conversion to Dementia

This study quantified metabolic resilience using FDG-PET imaging in 848 participants from the ADNI database to assess its role in predicting cognitive decline and dementia conversion. Results showed that preserved brain glucose metabolism independently predicted slower cognitive decline and reduced dementia conversion risk, suggesting it is a valuable biomarker complementary to structural brain measures.