Asymmetrical β-amyloid deposition patterns and cognitive decline in Alzheimer's disease: findings from the SILCODE study

This longitudinal study examined asymmetric distribution of β-amyloid plaques across the brain in 148 participants spanning normal cognition to Alzheimer's disease dementia. The research found that β-amyloid lateralization varies by disease stage and correlates with cognitive performance, suggesting potential utility as a neuroimaging biomarker for tracking disease progression.