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StudiuParkinsonÎncredere înaltă22.06.2026

Blepharoclonus in Parkinsonism: Frequency and Diagnostic Utility

This prospective study assessed the prevalence of blepharoclonus (eyelid fluttering) in 75 Parkinson's disease patients and 10 with atypical parkinsonism, finding it present in 84% of PD cases and 60% of synucleinopathy cases but absent in non-synucleinopathy parkinsonian syndromes. The findings suggest blepharoclonus may have diagnostic utility in differentiating synucleinopathy-associated parkinsonism from other parkinsonian conditions.

StudiuParkinsonÎncredere înaltă22.06.2026

New horizons in Parkinson's disease in older populations

Parkinson's disease is the second most common neurodegenerative disorder, with aging as the primary risk factor; prevalence is expected to increase globally due to population aging. Current treatments manage symptoms rather than cure the disease, and management is complicated by multiple comorbidities in older adults; this review examines disease management strategies and emerging care models aimed at improving quality of life.

StudiuParkinsonÎncredere bună22.06.2026

Functional Movement Disorder Comorbidity in Parkinson's Disease: A Multicenter Descriptive Study

This multicenter study investigates the co-occurrence of functional movement disorders alongside Parkinson's disease diagnosis. The research provides descriptive clinical data on how these movement conditions present together, contributing to understanding of complex neurological presentations in affected populations.

StudiuParkinsonÎncredere înaltă21.06.2026

The RAB32 p.Ser71Arg Variant in Parkinsonisms: Insights from a Large Italian Cohort

A study of 4,600 Italian patients with Parkinson's disease or atypical parkinsonism identified 20 new carriers of the RAB32 p.Ser71Arg variant, which was associated with earlier disease onset (average 51 years) and good response to dopaminergic therapy. Carriers showed positive family history in 55.5% of cases, suggesting dominant inheritance patterns, with generally preserved cognitive function and mild psychiatric symptoms.

StudiuParkinsonÎncredere înaltă21.06.2026

Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease

This expert consensus document provides evidence-based clinical guidance on screening, diagnosis, and treatment of gastrointestinal dysfunction in Parkinson disease, a common non-motor symptom that can precede motor symptoms and significantly impact quality of life. Recommendations are organized by anatomical segments (oral cavity, esophagus, stomach, small intestine, colon) based on a modified Delphi panel approach involving movement disorder neurologists and gastroenterologists.

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