POLG-associated Parkinson's disease-ALS overlap: Novel variant and first use of continuous subcutaneous foslevodopa/foscarbidopa infusion
A 38-year-old patient with a rare POLG gene variant developed an unusual overlap syndrome combining young-onset Parkinson's disease with ALS-like features (Brait-Fahn-Schwartz disease). Continuous subcutaneous infusion of foslevodopa/foscarbidopa achieved significant motor improvement at twelve months, representing the first documented use of this device-based therapy in this genetic condition.