NeuroPsy InfoHub adună studii și articole verificate editorial despre sănătate mintală și afecțiuni neurologice — pentru pacienți, familii și specialiști.
A cross-sectional study of 268 pregnant women examined the prevalence of Down syndrome screening using dual and quadruple serum marker tests during weeks 11-22 of gestation. Among 200 screened women (74.63%), 84% showed low-risk results and 16% showed high-risk results, with findings comparable to similar institutional studies.
Children with Down syndrome (Trisomy 21) commonly present with various ocular complications including strabismus, nystagmus, refractive errors, congenital cataracts, keratoconus, and reduced visual acuity. Early ophthalmic examination and prompt intervention are essential for diagnosis and management of these vision-related manifestations.
This editorial addresses endocrine complications commonly associated with Down syndrome, including thyroid dysfunction, metabolic issues, and growth abnormalities. The piece discusses clinical manifestations and management considerations for healthcare providers treating individuals with Down syndrome across the lifespan.
Individuals with Down syndrome experience dysregulation of both innate and adaptive immune systems, resulting in increased susceptibility to autoimmunity and severe infections compared to the general population. Documented immune alterations include elevated cytokine levels, increased interferon signaling, shifts toward memory T-cell phenotypes, and reduced B-cell compartment size, which contribute to both autoinflammatory conditions and heightened infection severity.
This case report describes a 10-year-old girl with Down syndrome presenting with abnormal gait and ataxia caused by atlantoaxial subluxation, a known complication resulting from ligament laxity and odontoid dysplasia. The condition was surgically managed after diagnosis through imaging.