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This perspective examines clathrin-mediated endocytosis (CME), a cellular uptake process, as a key mechanism underlying Parkinson's disease risk based on genetic and functional evidence from both inherited and sporadic forms. The article explores how CME dysfunction may contribute to neurodegeneration and discusses therapeutic targeting of CME pathways as a potential approach to treating Parkinson's disease.
This PET imaging study compared cholinergic system function in tremor-dominant versus non-tremor-dominant Parkinson's disease patients using [11C]-donepezil binding. Results showed preserved cholinergic function in tremor-associated regions of tremor-dominant patients but decreased cholinergic binding in multiple brain regions of non-tremor-dominant patients, suggesting differential cholinergic pathology between Parkinson's disease subtypes.
This review examines how animal models have been used to evaluate novel compounds for Parkinson's disease treatments, including drugs targeting levodopa-induced dyskinesia, disease modification, and parkinsonism symptoms. The authors analyze multiple clinical trial candidates and discuss both successes and failures in predicting clinical efficacy from preclinical studies, offering insights into optimizing animal model design for better translational success.
A prospective multicentre study of 151 early-stage parkinsonism patients found that detection of phosphorylated α-synuclein in skin nerve fibres achieved 81% sensitivity and 100% specificity for identifying Parkinson's disease versus other parkinsonian disorders. Skin biopsy biomarker analysis, combined with clinical follow-up over 46 months, may help differentiate true PD from mimicking conditions in early diagnostic stages.
This systematic review examined 16 studies investigating enteral nutrition's effects on survival and complications in Parkinson's disease and atypical parkinsonism, finding moderate-to-high risk of bias across all included studies. Despite aspiration pneumonia occurring in ~40% of parkinsonism patients after enteral feeding, evidence remains insufficient to conclusively demonstrate improved survival, with weighted median survival around 1.35-1.49 years post-gastrostomy.