Clathrin-mediated endocytosis as a pathogenic mechanism in Parkinson's disease

This perspective examines clathrin-mediated endocytosis (CME), a cellular uptake process, as a key mechanism underlying Parkinson's disease risk based on genetic and functional evidence from both inherited and sporadic forms. The article explores how CME dysfunction may contribute to neurodegeneration and discusses therapeutic targeting of CME pathways as a potential approach to treating Parkinson's disease.