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StudiuDemențeÎncredere înaltă20.06.2026

Cerebrospinal Fluid Proteomics Identifies Proteins Associated with Cognitive Decline in Amyloid-Beta Positive Older Adults

This proteomics study analyzed cerebrospinal fluid from 490 amyloid-positive participants to identify 61 dysregulated proteins that distinguish those with Alzheimer's dementia from cognitively normal or mildly impaired individuals. The identified proteins were associated with cognitive progression and diagnostic conversion, with functional enrichment analyses revealing pathways relevant to neurodegeneration.

StudiuDemențeÎncredere înaltă20.06.2026

Genome-Wide Analysis of Memory, Language, and Executive Function Reveals Domain-Specific Genetic Architecture in Alzheimer Disease

This genome-wide association study investigates the distinct genetic factors underlying specific cognitive domains (memory, language, executive function) affected in Alzheimer's disease. The research identifies domain-specific genetic architecture, suggesting that different cognitive impairments in AD may have partially distinct genetic underpinnings.

StudiuDemențeÎncredere bună20.06.2026

TLRs and NLRs in Oral Microbiome Involvement in Alzheimer's Disease Pathogenesis

This research examines how oral microbiome dysbiosis contributes to Alzheimer's disease through TLR/NLR immune signaling pathways that trigger systemic and neuroinflammation. The oral microbiome composition is proposed as a potential biomarker for early diagnosis and screening of cognitive decline, with discussion of targeted therapeutic approaches like TLR/NLR inhibitors.

StudiuDemențeÎncredere înaltă20.06.2026

Sex-specific sleep disturbances worsen psychiatric symptoms and cognitive decline in Alzheimer's disease

This clinical study analyzed 184 Alzheimer's disease patients stratified by sex to examine relationships between sleep disturbances, neuropsychiatric symptoms, and cognitive progression. Patients with disturbed sleep showed worse cognitive performance and higher rates of depression, anxiety, and behavioral problems, with sex-specific patterns: women exhibited more disinhibition and depression while men showed greater cognitive decline and higher caregiver burden.