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StudiuAVC și AITÎncredere bună30.06.2026

Soluble Suppression of Tumorigenicity 2 as a Biomarker for Atrial Fibrillation Detected After Stroke: A Retrospective Clinical Study

This retrospective study of 970 stroke/TIA patients found that elevated sST2 levels independently predicted atrial fibrillation detection after stroke (AFDAS), with sST2 showing superior predictive value (AUC 0.815) compared to conventional risk factors. Adding sST2 to a conventional risk model significantly improved prediction accuracy for AFDAS in acute stroke patients.

StudiuDemențeÎncredere înaltă30.06.2026

The impact of loneliness and social isolation on cognitive decline and Alzheimer's disease development

This review examines the relationship between loneliness and social isolation as major risk factors for Alzheimer's disease and cognitive decline, with particular attention to sex differences. The authors discuss mechanisms linking isolation to AD pathology and propose approaches for developing prevention and treatment strategies based on understanding these associations.

StudiuDemențeÎncredere bună30.06.2026

Mobile Software Application for Cognitive-Communication Support in Alzheimer's Disease: Development and Efficacy Study

Researchers developed a tablet-based software application designed to slow cognitive and communicative decline in individuals with Alzheimer's disease for home use. A randomized controlled trial with 32 participants (mild, moderate, and severe stages) compared outcomes between those using the application plus pharmacological treatment versus pharmacological treatment alone.

StudiuDemențeÎncredere bună30.06.2026

Cost Analysis of Imaging-Guided Lecanemab Treatment in Alzheimer's Disease: Three-Year Projections

This health economics study examines costs associated with using neuroimaging (PET and MRI) to identify Alzheimer's disease patients most likely to benefit from lecanemab treatment over three years. The authors highlight a critical concern: approximately 78% of patients with mild cognitive impairment do not progress to dementia, making prophylactic treatment in all MCI patients costly and ethically problematic; they identify combined fluorodeoxyglucose and MRI imaging as the most cost-efficient approach at $177,000 per positive outcome with adjusted lecanemab pricing.

StudiuAdicțiiÎncredere bună30.06.2026

Neural fingerprints of gambling disorder using diffusion tensor imaging

This neuroimaging study compared brain structural connectivity in 25 individuals with gambling disorder versus 28 healthy controls using diffusion tensor imaging and probabilistic tractography. The gambling disorder group showed increased striatal connectivity but reduced frontal lobe connectivity and fewer neural hubs, suggesting impaired network integration related to risk-taking control.

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