Corneal confocal microscopy reveals varying degrees of nerve loss in Parkinson's disease and atypical parkinsonian disorders
This study used corneal confocal microscopy to detect corneal nerve loss as a potential biomarker for neurodegeneration in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. Corneal nerve fiber density was significantly reduced in all three patient groups compared to healthy controls, with the most pronounced changes in multiple system atrophy, suggesting this imaging technique may help differentiate these neurodegenerative conditions.