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Researchers developed a surface-enhanced Raman scattering (SERS) detection platform coupled with machine learning algorithms to identify transient ischemic attacks (TIA) through inflammatory markers in serum. The system achieved 99.64% accuracy using LightGBM and demonstrated robust performance across multiple deep learning models (>90% accuracy), with results validated against clinical diagnoses.
This meta-analysis examined ten protein biomarkers across 18,160 acute ischemic stroke (AIS) and 3,410 transient ischemic attack (TIA) patients to identify biomarkers that could improve diagnostic differentiation between these two conditions. Five biomarkers showed statistically significant differences between AIS and TIA groups: S100B, sNfl, copeptin, IL-6, and MMP-9, with MMP-9 demonstrating the largest concentration differential.
This systematic review and meta-analysis of 50 studies demonstrates that head and neck cancer patients receiving radiation therapy have a significantly increased risk of ischemic stroke (8.98 per 1,000 person-years) and carotid stenosis compared to surgical or non-treated populations. The relative risk of stroke is approximately 1.3 times higher in irradiated patients, with carotid stenosis incidence ranging from 0-40% depending on follow-up duration.
This Norwegian registry study tracked over 229,000 incident stroke cases across 20 years, finding overall declining stroke incidence in both sexes, though ischemic stroke increased 1.6% annually in men under 35 years old. Transient ischemic attack incidence rose sharply until 2012 then declined substantially thereafter.
This narrative review examines why anticoagulation fails in some patients with patent foramen ovale (PFO)-related cryptogenic stroke, synthesizing evidence showing transcatheter closure is superior to medical therapy in appropriately selected patients. The analysis incorporates pathophysiological mechanisms, randomized trial comparisons, and risk stratification tools (RoPE score, PASCAL classification) to guide optimal therapeutic selection.