Protein Biomarkers for Distinguishing Acute Ischemic Stroke from Transient Ischemic Attack: A Meta-Analysis

This meta-analysis examined ten protein biomarkers across 18,160 acute ischemic stroke (AIS) and 3,410 transient ischemic attack (TIA) patients to identify biomarkers that could improve diagnostic differentiation between these two conditions. Five biomarkers showed statistically significant differences between AIS and TIA groups: S100B, sNfl, copeptin, IL-6, and MMP-9, with MMP-9 demonstrating the largest concentration differential.