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StudiuSindrom DownÎncredere înaltă27.06.2026

Multiomics and proteomic insights into Alzheimer's disease biology in Down syndrome

This scientific review synthesizes findings from brain, cerebrospinal fluid, and blood-based proteomic studies to characterize molecular pathways underlying Alzheimer's disease in Down syndrome, with focus on disruption of proteostasis, mitochondrial function, and immune signaling. The analysis positions Down syndrome-associated Alzheimer's disease as a network-level disorder where amyloid and tau pathology interact with immune responses, providing insights applicable to broader Alzheimer's disease biology.

StudiuSindrom DownÎncredere bună27.06.2026

Necroptosis in Down Syndrome: Evidence from Animal Models and Human Brain Tissue

Researchers identified elevated necroptosis markers (RIPK1, RIPK3, MLKL, and lncRNA MEG) in brains of aged Ts65dn mice and post-mortem tissue from Down syndrome subjects, suggesting this controlled cell death pathway may contribute to neuronal loss in DS. These findings propose necroptosis as a potential therapeutic target for developing new treatments in Down syndrome.

StudiuSindrom DownÎncredere înaltă23.06.2026

Social Cognition Development in Children and Adolescents With Down Syndrome: A Scoping Review

This systematic scoping review of 40 peer-reviewed studies (2008-2024) examined social cognition development in children and adolescents with Down syndrome, finding that language is the primary factor influencing social cognitive development rather than age alone. Individuals with Down syndrome demonstrate challenges in social cognition and emotion processing compared to typical development, with the review calling for more longitudinal research to clarify developmental trajectories and inform educational and clinical interventions.

StudiuSindrom DownÎncredere înaltă22.06.2026

Ophthalmologic and neuro-ophthalmologic findings in children with Down syndrome

Children with Down syndrome (Trisomy 21) commonly present with various ocular complications including strabismus, nystagmus, refractive errors, congenital cataracts, keratoconus, and reduced visual acuity. Early ophthalmic examination and prompt intervention are essential for diagnosis and management of these vision-related manifestations.