Necroptosis in Down Syndrome: Evidence from Animal Models and Human Brain Tissue

Researchers identified elevated necroptosis markers (RIPK1, RIPK3, MLKL, and lncRNA MEG) in brains of aged Ts65dn mice and post-mortem tissue from Down syndrome subjects, suggesting this controlled cell death pathway may contribute to neuronal loss in DS. These findings propose necroptosis as a potential therapeutic target for developing new treatments in Down syndrome.