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StudiuSindrom DownÎncredere înaltă22.06.2026

Voxel-based dysconnectomic brain morphometry with computed tomography in Down syndrome

This cross-sectional study analyzed CT scans from 98 adults with Down syndrome using automated voxel-based morphometry to identify brain volume changes associated with dementia severity and Alzheimer's disease biomarkers. Results showed negative correlations between dementia stage and gray/white matter volumes in temporal lobe regions, with dysconnectomic patterns linking white matter loss to hippocampal atrophy, providing a faster neuroimaging alternative to MRI for this population.

StudiuSindrom DownÎncredere înaltă22.06.2026

Management of Residual Obstructive Sleep Apnoea After Adenotonsillectomy in Children with Down Syndrome: A Tertiary Sleep Service Experience

This retrospective study of 100 children with Down syndrome who underwent surgery for obstructive sleep apnoea found that 68% developed residual sleep-disordered breathing postoperatively. The research demonstrates that CPAP therapy can be successfully established in most affected children, with approximately one-third requiring additional surgical interventions to manage persistent symptoms.

StudiuSindrom DownÎncredere înaltă22.06.2026

Down syndrome and leukemia: Disease biology and current treatment approaches

Children with Down syndrome have a significantly elevated risk of developing acute leukemia, particularly myeloid types, with distinct mutational patterns and treatment challenges compared to non-DS populations. Current evidence from animal and stem cell models is advancing understanding of leukemia initiation mechanisms in DS, while clinical strategies focus on balancing efficacy against chemotherapy toxicity specific to this population.

StudiuSindrom DownÎncredere bună22.06.2026

Dynamic gait stability in children with and without Down syndrome during overground walking

This study compared gait stability in 24 children with and without Down syndrome under different walking speeds and ankle load conditions using margin-of-stability measurements. Children with Down syndrome demonstrated greater mediolateral stability but variable anteroposterior stability patterns, with ankle loads affecting mediolateral but not anteroposterior stability parameters.

StudiuSindrom DownÎncredere înaltă22.06.2026

Healthcare Transition Roadmap for Young Adults with Down Syndrome to Adulthood

Healthcare transition for young adults with Down syndrome requires a purposeful, longitudinal, and holistic approach to prepare them for adult-oriented healthcare systems. The framework uses six core elements—policy, tracking, readiness, planning, transfer of care, and complete transition—along with practical tools like TRAQ and portable medical summaries to address common gaps in care.