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StudiuSindrom DownÎncredere bună29.06.2026

Emerging adults' emotional responses toward siblings with Down syndrome: The role of support, optimism, and sense of coherence

This study examined 292 emerging adult siblings (ages 18-27) of individuals with Down syndrome to identify factors influencing their emotional responses toward their affected sibling. Higher social support and optimism predicted more positive emotions, while stronger sense of coherence was associated with fewer negative emotions; sibling functionality and religious affiliation also moderated these relationships.

StudiuSindrom DownÎncredere înaltă27.06.2026

Cancer Frequencies and Screening in Individuals With Down Syndrome: A Comprehensive Nationwide Cross-Sectional Analysis

This large German study of 46,362 individuals with Down syndrome found lower overall cancer prevalence compared to matched controls, but significantly elevated risks for hematologic malignancies and testicular cancer, while breast, digestive, and skin cancers were less frequent. Notably, individuals with Down syndrome participated in cancer screening programs at substantially lower rates, highlighting a gap in preventive care access and adherence.

StudiuSindrom DownÎncredere înaltă27.06.2026

Multiomics and proteomic insights into Alzheimer's disease biology in Down syndrome

This scientific review synthesizes findings from brain, cerebrospinal fluid, and blood-based proteomic studies to characterize molecular pathways underlying Alzheimer's disease in Down syndrome, with focus on disruption of proteostasis, mitochondrial function, and immune signaling. The analysis positions Down syndrome-associated Alzheimer's disease as a network-level disorder where amyloid and tau pathology interact with immune responses, providing insights applicable to broader Alzheimer's disease biology.

StudiuSindrom DownÎncredere bună27.06.2026

Necroptosis in Down Syndrome: Evidence from Animal Models and Human Brain Tissue

Researchers identified elevated necroptosis markers (RIPK1, RIPK3, MLKL, and lncRNA MEG) in brains of aged Ts65dn mice and post-mortem tissue from Down syndrome subjects, suggesting this controlled cell death pathway may contribute to neuronal loss in DS. These findings propose necroptosis as a potential therapeutic target for developing new treatments in Down syndrome.