Cancer Frequencies and Screening in Individuals With Down Syndrome: A Comprehensive Nationwide Cross-Sectional Analysis

This large German study of 46,362 individuals with Down syndrome found lower overall cancer prevalence compared to matched controls, but significantly elevated risks for hematologic malignancies and testicular cancer, while breast, digestive, and skin cancers were less frequent. Notably, individuals with Down syndrome participated in cancer screening programs at substantially lower rates, highlighting a gap in preventive care access and adherence.