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Autism

Spectrul autist și particularitățile asociate.

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StudiuAutismÎncredere înaltă26.06.2026

Systematic Curation of Genetic Variants Associated with Autism Spectrum Disorder Using the EAGLE Framework

This study applied the Evaluation of Autism Gene Link Evidence (EAGLE) framework to systematically curate 222 genes associated with neurodevelopmental disorders, identifying 78 with definitive evidence for autism association, 43 with moderate evidence, and 99 with limited evidence. The analysis revealed differential expression and enrichment patterns at brain and cellular levels, establishing biological relevance for distinguishing autism-specific genetic associations from broader neurodevelopmental disorder phenotypes.

StudiuAutismÎncredere înaltă26.06.2026

EEG and Self-Report Reveal Intact Cognitive Appraisal but Reduced Affective-Sensorimotor Resonance for Others' Pain in Autism

This EEG study comparing adults with autism and neurotypical controls found that both groups could cognitively assess whether others experienced pain equally well. However, autistic adults showed reduced emotional and sensorimotor responses (measured via neural oscillations and self-report) when learning that a person could feel pain, suggesting differences in affective empathy rather than pain understanding.

StudiuAutismÎncredere bună26.06.2026

Smart sensing the spectrum: biosensor and biomarker approaches for early autism detection

This article reviews emerging biomarker research and biosensor technologies for earlier, more objective detection of autism spectrum disorder, moving beyond subjective behavioral assessments. The review covers protein-based biomarkers (amino acids, neurotransmitters), genetic variants (SNPs, CNVs), neuroimaging approaches (MRI/fMRI), and innovations in nanotechnology-enabled biosensors for non-invasive real-time monitoring.

StudiuAutismÎncredere înaltă26.06.2026

Factors Associated with Resilience Among Parents of Children with Autism Spectrum Disorder: A Systematic Review

This systematic review identified five key themes influencing resilience in parents of children with ASD: sociodemographic/economic factors, child characteristics, parenting well-being, psychological factors/coping styles, and social support. The findings emphasize that parental resilience is multifactorial, influenced by psychological, social, and contextual elements, though most included studies were cross-sectional, limiting causal inference.

StudiuAutismÎncredere bună26.06.2026

Timing of Childhood Adversity and Cognitive Profiles in Adults with Autism Spectrum Disorder

This study investigated 161 autistic adults without intellectual disability, categorizing them by timing of adverse childhood experiences (ACEs) and comparing cognitive abilities using standardized intelligence testing. Results indicated that early ACE exposure (≤10 years) was associated with different performance patterns on specific cognitive subtests compared to adolescent ACE exposure, with differences persisting even after controlling for PTSD symptom severity.

StudiuAutism + ADHDÎncredere bună26.06.2026

Symptomatic hyperprolactinemia mimicking pituitary pathology in a child with Landau-Kleffner syndrome and autism spectrum disorder: case report

A 12-year-old girl with autism spectrum disorder, Landau-Kleffner syndrome, and intellectual disability developed galactorrhea, vision problems, and falls while taking risperidone, with laboratory findings showing elevated prolactin (40.2 ng/mL) but normal imaging excluding pituitary tumor. Switching from risperidone to olanzapine resulted in complete symptom resolution and prolactin normalization (2.2 ng/mL) within three months, highlighting the importance of monitoring prolactin levels in children on antipsychotic medication.

StudiuAutismÎncredere bună26.06.2026

Awareness of Autism Spectrum Disorder and Symptom Recognition Among General Practitioners: A Cross-Sectional Study

This survey of 242 GPs assessed their knowledge of autism spectrum disorder symptoms, referral practices, and attitudes toward ASD etiology and treatment. While most GPs recognized core social communication symptoms, significant knowledge gaps existed regarding sensory symptoms and atypical presentations, with postgraduate ASD training associated with improved recognition competence.

StudiuAutismÎncredere bună26.06.2026

Assessment of Knowledge, Attitudes, and Behaviors Regarding Autism Spectrum Disorder Among Sixth-Year Medical Students in Izmir

This cross-sectional study evaluated 748 medical students in Turkish universities using validated questionnaires to assess their knowledge about ASD and societal attitudes toward autism. Results showed that while two-thirds attended ASD training, 39.4% lacked confidence in managing suspected ASD cases, and students with prior clinical experience or personal connections to individuals with ASD demonstrated significantly better knowledge and more positive attitudes.

StudiuAutismÎncredere înaltă26.06.2026

Comparison of Video Modeling and Video-Animated Modeling for Teaching Social-Affective Behaviors in Children with Autism Spectrum Disorder

This single-case study evaluated the effectiveness of video modeling (VM) and video-animated modeling (VAM) in teaching three social-affective behaviors (verbal/facial expressions and gestures) to 3 children aged 4-6 years with ASD. Both interventions proved effective with variable efficiency across participants, and caregivers and teachers reported positive social validity outcomes.

StudiuAutismÎncredere bună26.06.2026

Zinc protects cerebellar structure and reduces oxidative stress in a propionic acid-induced autism spectrum disorder rat model

This preclinical study in rats examined whether zinc supplementation could protect against cerebellar damage and behavioral impairment induced by propionic acid, a short-chain fatty acid implicated in ASD models. Zinc treatment significantly reduced Purkinje neuron degeneration, normalized glial and neuronal biomarkers, and improved anxiety-like and social interaction deficits, suggesting a potential protective mechanism through oxidative stress reduction.

StudiuAutismÎncredere bună26.06.2026

Serum fatty acid-binding protein 4 as a potential biomarker for autism spectrum disorder: a comparative cross-sectional study

This study examined serum FABP4 levels in 90 children (ages 3-12) across three groups: autism spectrum disorder, intellectual disability, and healthy controls. Results showed significantly lower FABP4 in both ASD and ID groups versus controls, with strong diagnostic accuracy for distinguishing ASD and ID from controls, but limited ability to differentiate ASD from intellectual disability.

StudiuAutismÎncredere înaltă26.06.2026

Mealtime behaviors, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Türkiye

This study of 111 Turkish families found that 94.5% of children with ASD had poor diet quality, with problematic mealtime behaviors being a strong independent predictor of lower dietary quality. While proactive parental strategies improved diet quality, accommodative practices like preparing separate meals were associated with poorer outcomes, and parents of girls with ASD reported significantly higher stress levels.

StudiuAutismÎncredere bună26.06.2026

Biochemical Biomarker Profiles in Peripheral Blood of Valproic Acid-Induced Autism Model Rats Across Development

This experimental study investigated developmental changes in peripheral blood biomarkers (BDNF, neurotrophins, cytokines, serotonin) in rats with autism-like features induced prenatally using valproic acid and poly I:C. Behavioral screening confirmed autism phenotypes, and blood samples were analyzed at 2, 4, 6, and 8 weeks of age to characterize biochemical alterations.

PresăAutismÎncredere bună25.06.2026

Dogs May Bridge the Autism Drug Discovery Gap

Shank3 mutant beagles represent a potentially valuable preclinical model for autism research due to their naturally evolved social behaviors that more closely resemble human autism phenotypes than rodent models. This approach aims to address the high failure rate in translating autism drug candidates from animal studies to human clinical trials.

StudiuAutismÎncredere bună25.06.2026

Maternal Exposure to Lithium in Drinking Water and Autism Spectrum Disorder Risk in Danish Offspring

A nationwide Danish case-control study examined whether prenatal maternal exposure to naturally occurring lithium in drinking water is associated with autism spectrum disorder (ASD) diagnosis in offspring, using geocoded residential addresses and water quality measurements. The research leverages biological plausibility (lithium's role in neurodevelopmental signaling pathways) and population-based registry data to evaluate this environmental exposure hypothesis.

StudiuAutism + ADHDÎncredere bună24.06.2026

Effect of Prior Depression Diagnosis on Bipolar Disorder Outcomes: A Retrospective Cohort Study

This retrospective cohort study analyzed 5,595 Japanese patients newly diagnosed with bipolar disorder to examine whether a prior depression diagnosis and its duration affected psychiatric and all-cause hospitalization rates and mortality. Patients with prior depression history showed slightly lower all-cause hospitalization risk (HR=0.87), with duration of preceding depression (≥1 year vs <1 year) not significantly altering psychiatric hospitalization outcomes.

StudiuAutismÎncredere înaltă23.06.2026

Association between autism and psychosis: Systematic review and meta-analysis of measurement tools

This meta-analysis of 63 studies (N=6.9 million) found significant associations between autism and psychosis-spectrum traits across multiple dimensions, with individuals having one condition showing increased risk of being diagnosed with the other. The research highlights that measurement validity and potential misinterpretation of psychosis questionnaires by autistic individuals and clinicians may contribute to these associations.

StudiuAutism + ADHDÎncredere bună23.06.2026

Autism in Schizophrenia and Its Original Link to Self-Disorder: Returning a Borrowed Concept

This academic paper traces the historical origins of the term 'autism' coined by Eugen Bleuler in 1910 to describe schizophrenia, and how the concept was later borrowed to describe autism spectrum disorder, leading to diagnostic confusion. The authors argue that autistic features in schizophrenia differ fundamentally from autism spectrum disorder—rooted in self-disorder rather than developmental autism—and propose this distinction is crucial for accurate differential diagnosis and appropriate treatment.