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AVC și AIT

Accident vascular cerebral și recuperare, la orice vârstă.

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StudiuAVC și AITÎncredere înaltă22.06.2026

Individualized Interpretation of FLAIR Vessel Hyperintensity in Ischemic Stroke and Transient Ischemic Attack: A Systematic Review

This systematic review examines FLAIR vessel hyperintensity (FVH), an imaging finding reflecting critically slowed blood flow in large artery steno-occlusions, and its clinical significance for predicting prognosis, stroke severity, infarction volume, and functional outcomes in acute ischemic stroke and TIA. The authors address conflicting findings in the literature and propose key factors for individualizing clinical interpretation of this neuroimaging marker to guide clinical decision-making.

StudiuAVC și AITÎncredere înaltă22.06.2026

Cost-Effectiveness of CYP2C19 Genotype-Guided Antiplatelet Therapy for Acute Minor Ischemic Stroke and High-Risk TIA in China

A pharmacoeconomic study evaluated whether personalizing antiplatelet therapy based on CYP2C19 genetic testing (using cilostazol or ticagrelor) is cost-effective compared to standard clopidogrel plus aspirin treatment for minor stroke and high-risk transient ischemic attack in China. The analysis found genotype-guided strategies were cost-effective with incremental cost-effectiveness ratios below accepted thresholds, with robust results across sensitivity analyses.

StudiuAVC și AITÎncredere înaltă22.06.2026

Cardiac complications following cerebrovascular disease: Comparative analysis of stroke types

This study examined cardiac complications in 721 stroke patients across three cerebrovascular event types (ischemic stroke, transient ischemic attack, and hemorrhagic stroke). Results showed ECG changes were most frequent in ischemic stroke (81.7%), with myocardial alterations common across all groups, suggesting important brain-heart interactions following stroke.

StudiuAVC și AITÎncredere bună22.06.2026

Dipping Pattern and 1-Year Stroke Functional Outcome in Ischemic Stroke or Transient Ischemic Attack

This cohort study of 1,808 patients examined whether nocturnal blood pressure dipping patterns predict 1-year functional outcomes after stroke or TIA. While reverse dipping (less than 0% nocturnal systolic BP drop) was associated with worse outcomes in initial analysis, this association became non-significant after adjusting for confounding variables.

StudiuAVC și AITÎncredere înaltă21.06.2026

Accelerated Biological Aging as a Predictor of Short- and Long-term Stroke Outcomes in Ischemic Stroke and TIA Patients

This prospective study of 7,396 stroke/TIA patients from China found that accelerated biological age—calculated using three established algorithms (PhenoAge, Klemera-Doubal, HD)—is associated with increased risk of poor stroke outcomes both short- and long-term. Patients with the highest PhenoAge acceleration showed nearly double the risk of adverse events compared to those with the lowest acceleration.

StudiuAVC și AITÎncredere bună21.06.2026

Association between Telomere Length and Neurological Disability in Stroke Patients: Analysis by Stroke Type

This prospective study of 271 stroke patients examined the relationship between telomere length (a cellular aging marker) and neurological disability measured by standardized clinical scales (NIHSS and mRS). Shorter telomeres were associated with higher stroke severity scores in ischemic stroke patients, both at emergency department admission and one day later.

StudiuAVC și AITÎncredere bună21.06.2026

Electromagnetic Fields in Ischemic Stroke Rehabilitation and Monitoring: From Laboratory to Clinical Application

This review examines the use of electromagnetic field therapies (including transcranial magnetic stimulation, transcranial direct current stimulation, and pulsed electromagnetic fields) as adjunctive rehabilitation approaches for stroke patients beyond conventional thrombolytic and thrombectomy interventions. The paper discusses the physical principles, molecular mechanisms, and evidence from preclinical and clinical studies supporting EMF applications in functional recovery and stroke monitoring.

StudiuAVC și AITÎncredere înaltă21.06.2026

Systematic Review and Meta-Analysis of Antithrombotic Therapy Delivery Within 48 Hours of Ischemic Stroke

This meta-analysis of 45 audits covering 1.18 million stroke patients found that 81.1% received antithrombotic therapy within 48 hours, falling below the 85% quality benchmark established by stroke care guidelines. Treatment delivery rates were comparable between high-income and low-to-middle-income countries, with improvements noted in studies published after 2008.

StudiuAVC și AITÎncredere înaltă21.06.2026

Comparison of American and European Guideline Recommendations for Diagnostic Workup and Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack

This study compares stroke diagnostic and secondary prevention recommendations between American Heart Association/American Stroke Association (AHA/ASA) and European Stroke Organization (ESO) guidelines, analyzing 63 ESO and 82 AHA/ASA recommendations across 7 key topics. While most recommendations are similar, the guidelines assign different levels of evidence quality to many recommendations, with notable discrepancies in high-level evidence classifications.

StudiuAVC și AITÎncredere bună21.06.2026

Preventability of Ischemic Stroke and Transient Ischemic Attack in a Tertiary Care Center in Argentina

This retrospective study evaluated patients with acute ischemic stroke or transient ischemic attack to assess how many cases could have been prevented through better management of vascular risk factors such as hypertension, dyslipidemia, atrial fibrillation, and smoking. The researchers developed a 10-point preventability scale to classify the degree to which each event was avoidable based on the optimization of modifiable risk factors at presentation.

StudiuAVC și AITÎncredere bună20.06.2026

Left Atrial Reservoir Strain as a Predictor of Cardioembolic Ischemic Stroke and Atrial Fibrillation

This retrospective study evaluated left atrial reservoir strain using echocardiography in 79 stroke/TIA patients without prior atrial fibrillation history to identify cardiac sources of emboli. Reduced reservoir strain was associated with cardioembolic stroke mechanisms and atrial fibrillation occurrence, suggesting it may aid in stroke risk stratification and AF detection.

StudiuAVC și AITÎncredere bună20.06.2026

Cerebrovascular Events and Associated Risk Factors in Cervical Fibromuscular Dysplasia: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis examines the incidence and risk factors for cerebrovascular events (including stroke) in patients with cervical fibromuscular dysplasia, a non-atherosclerotic vascular condition affecting arterial walls. The study synthesizes evidence to characterize stroke risk and associated factors in this patient population.

StudiuAVC și AITÎncredere bună20.06.2026

Early diagnosis of transient ischemic attack using SERS-based artificial intelligence sensors

Researchers developed a surface-enhanced Raman scattering (SERS) detection platform coupled with machine learning algorithms to identify transient ischemic attacks (TIA) through inflammatory markers in serum. The system achieved 99.64% accuracy using LightGBM and demonstrated robust performance across multiple deep learning models (>90% accuracy), with results validated against clinical diagnoses.

StudiuAVC și AITÎncredere bună20.06.2026

Protein Biomarkers for Distinguishing Acute Ischemic Stroke from Transient Ischemic Attack: A Meta-Analysis

This meta-analysis examined ten protein biomarkers across 18,160 acute ischemic stroke (AIS) and 3,410 transient ischemic attack (TIA) patients to identify biomarkers that could improve diagnostic differentiation between these two conditions. Five biomarkers showed statistically significant differences between AIS and TIA groups: S100B, sNfl, copeptin, IL-6, and MMP-9, with MMP-9 demonstrating the largest concentration differential.

StudiuAVC și AITÎncredere înaltă20.06.2026

Cerebrovascular Events After Head and Neck Radiation Therapy: Systematic Review and Meta-Analysis

This systematic review and meta-analysis of 50 studies demonstrates that head and neck cancer patients receiving radiation therapy have a significantly increased risk of ischemic stroke (8.98 per 1,000 person-years) and carotid stenosis compared to surgical or non-treated populations. The relative risk of stroke is approximately 1.3 times higher in irradiated patients, with carotid stenosis incidence ranging from 0-40% depending on follow-up duration.

StudiuAVC și AITÎncredere înaltă20.06.2026

Beyond Anticoagulation: Understanding Medical Therapy Failure in PFO-Related Stroke and the Case for Closure

This narrative review examines why anticoagulation fails in some patients with patent foramen ovale (PFO)-related cryptogenic stroke, synthesizing evidence showing transcatheter closure is superior to medical therapy in appropriately selected patients. The analysis incorporates pathophysiological mechanisms, randomized trial comparisons, and risk stratification tools (RoPE score, PASCAL classification) to guide optimal therapeutic selection.

StudiuAVC și AITÎncredere bună20.06.2026

Pre-stroke sleep quality predicts 1-year mortality and functional outcomes in ischemic stroke and TIA patients

This cohort study of 2,266 stroke/TIA patients found that poor pre-stroke subjective sleep quality (highest PSQI quartile) significantly increased 1-year mortality risk (3.73-fold) and poor functional outcome risk (2.15-fold) compared to good sleep quality. The association remained independent after adjusting for confounders, suggesting sleep quality as a prognostic marker in acute ischemic stroke.