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Parkinson

Boala Parkinson și tulburări de mișcare.

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StudiuParkinsonÎncredere înaltă19.06.2026

Experimental Pharmacology and Drug Development for Parkinson's Disease: Translating Animal Models to Clinical Outcomes

This review examines how animal models have been used to evaluate novel compounds for Parkinson's disease treatments, including drugs targeting levodopa-induced dyskinesia, disease modification, and parkinsonism symptoms. The authors analyze multiple clinical trial candidates and discuss both successes and failures in predicting clinical efficacy from preclinical studies, offering insights into optimizing animal model design for better translational success.

StudiuParkinsonÎncredere înaltă19.06.2026

Skin Intraneural Phosphorylated α-synuclein as a Highly Specific Biomarker for Early Parkinson's Disease

A prospective multicentre study of 151 early-stage parkinsonism patients found that detection of phosphorylated α-synuclein in skin nerve fibres achieved 81% sensitivity and 100% specificity for identifying Parkinson's disease versus other parkinsonian disorders. Skin biopsy biomarker analysis, combined with clinical follow-up over 46 months, may help differentiate true PD from mimicking conditions in early diagnostic stages.

StudiuParkinsonÎncredere bună19.06.2026

Enteral Nutrition in Idiopathic Parkinson's Disease and Atypical Parkinsonism: A Systematic Review

This systematic review examined 16 studies investigating enteral nutrition's effects on survival and complications in Parkinson's disease and atypical parkinsonism, finding moderate-to-high risk of bias across all included studies. Despite aspiration pneumonia occurring in ~40% of parkinsonism patients after enteral feeding, evidence remains insufficient to conclusively demonstrate improved survival, with weighted median survival around 1.35-1.49 years post-gastrostomy.

StudiuParkinsonÎncredere bună19.06.2026

Region-based morphometry in Parkinson's disease patients with GBA mutation and its predictive role for cognition after STN-DBS

This study used advanced brain imaging (region-based morphometry) to identify structural brain differences in Parkinson's disease patients carrying GBA mutations who underwent deep brain stimulation treatment. Researchers found significant atrophy in specific brain regions and tracked cognitive and motor outcomes, finding no significant cognitive decline one year after surgery despite baseline anatomical differences.

StudiuParkinsonÎncredere bună19.06.2026

The impact of cardiovascular disease on Parkinson's disease: Findings from the PPMI study

A cross-sectional analysis of 1,109 participants from the Parkinson's Progression Markers Initiative found that cardiovascular disease history was not associated with Parkinson's disease occurrence or progression in cognitive and autonomic domains, but was linked to higher risk of motor complications. The study used validated rating scales (MDS-UPDRS, SCOPA-AUT, MoCA) with a mean follow-up of 4.84 years in predominantly early-stage PD patients.

StudiuParkinsonÎncredere înaltă19.06.2026

Five-year cardiovascular and fall risk in Parkinson's disease patients with orthostatic hypotension: A nationwide cohort study

This large cohort study of 111,368 Parkinson's disease patients found that orthostatic hypotension independently increased the 5-year risk of falls by 35% and cumulative fall counts by 22%, but was not associated with major vascular events. Among patients with orthostatic hypotension, pharmacotherapy paradoxically correlated with higher fall risk, suggesting complex clinical trade-offs in managing this autonomic feature.

StudiuParkinsonÎncredere bună19.06.2026

Domain-specific severity profiles in a large Turkish Parkinson's disease cohort using MDS-UPDRS cut-offs

This multicenter cross-sectional study of 1,181 Turkish PD patients used validated MDS-UPDRS severity cut-offs to classify symptom burden across motor, non-motor, and functional domains. The analysis revealed that patient-reported non-motor and daily-living impairments were predominantly mild, while motor examination scores showed greater moderate-to-severe severity, with disease duration being the strongest clinical correlate.

StudiuParkinsonÎncredere bună19.06.2026

Comparative Analysis of Burnout Reduction Following Telerehabilitation in Neurological Patient Groups

This retrospective study evaluated burnout levels in 211 adults with various neurological conditions (hemiplegia/paraplegia/tetraplegia, Parkinson's disease, aphasia) before and after a standardized 6-week telerehabilitation program using validated outcome measures. Burnout scores significantly decreased across all diagnostic groups, with notably greater improvements in Parkinson's disease patients, and larger reductions observed in male participants and those aged 65 years or older.