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Epilepsie

Crize epileptice și managementul lor.

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StudiuEpilepsieÎncredere bună19.06.2026

Guidance for People with Epilepsy Participating in Sport and Exercise: A Narrative Review

This narrative review systematically examined publicly available documents and policies from national and international organizations published after 2016 regarding safe sport and exercise participation for people with epilepsy. The analysis identified recommendations across four themes for the general public and three themes for sports professionals, though only a quarter of reviewed documents specifically addressed the needs of individuals with comorbid intellectual disability or other neurological conditions.

StudiuEpilepsieÎncredere înaltă19.06.2026

Service evaluation of functional seizure recognition and management in a UK ambulance service

This survey of 96 ambulance staff from a UK NHS trust found that while paramedics frequently encounter functional seizures (82% report at least monthly presentations), 66% had received no formal training in recognizing or managing this condition. Despite high confidence levels among staff, the study reveals gaps in education and understanding of functional neurological disorders in pre-hospital care settings.

StudiuEpilepsieÎncredere bună19.06.2026

Canine Idiopathic Epilepsy as a Natural Animal Model for Human Epilepsy: A Scoping Review of Metabolic Perspectives

This scoping review examines canine idiopathic epilepsy as a naturally occurring model for human epilepsy, systematically synthesizing evidence on metabolic, immune, and microbiome alterations in affected dogs compared to healthy controls. The analysis covers multiple functional domains including amino acid/lipid metabolism, neurotransmission, oxidative stress, inflammation, and gut-brain axis pathways to identify translational relevance for human epilepsy research.

StudiuEpilepsieÎncredere înaltă19.06.2026

Disparities in epilepsy care: The role of provider decision-making.

This study analyzed over 17,000 clinic visits at a major epilepsy center to examine whether provider management decisions for seizures varied by patient race. Results showed Black patients were significantly more likely to be referred to epilepsy monitoring units after seizures compared to White patients, suggesting potential racial disparities in clinical decision-making despite controlling for seizure severity and socioeconomic factors.

StudiuEpilepsieÎncredere bună19.06.2026

Anti-seizure Medication Prescription Patterns in German Adults with Epilepsy: A Population-Based Retrospective Analysis (2018-2022)

This retrospective analysis examined anti-seizure medication (ASM) initiation and switching patterns in German epilepsy patients using statutory health insurance data from 2018-2022. Results showed over one-third of patients experienced delayed initial ASM prescription, levetiracetam remained the most commonly prescribed agent, and patients typically remained on first regimens for extended periods with inter-regimen switches averaging over 300 days.

StudiuEpilepsieÎncredere bună19.06.2026

Knowledge and Attitudes of Teachers and School Professionals Toward Epilepsy: Results of an Educational Program in Greece

This quasi-experimental study evaluated an educational program designed to improve epilepsy knowledge and attitudes among 471 primary school teachers in Western Greece, addressing documented gaps in seizure management understanding and stigmatizing beliefs. The intervention targeted common misconceptions and practical seizure response skills, with pre-post assessment measuring changes in teacher knowledge and attitudes.

StudiuEpilepsieÎncredere înaltă19.06.2026

MuGEP: Multiplex Graph-Based Brain Network Modeling for Epileptic Seizure Prediction Using Intracranial EEG

This research proposes MuGEP, a graph neural network framework that models diverse brain network relationships from intracranial EEG signals to improve seizure prediction accuracy. The method represents frequency band interactions across channels using multiplex graphs inspired by cross-frequency coupling in neuroscience, enabling more comprehensive analysis of epileptogenic brain networks.

StudiuEpilepsieÎncredere înaltă19.06.2026

Transcranial Magnetic Stimulation as a Translational Biomarker in Early-Phase Anti-Seizure Medication Development: A Randomized, Double-Blind, Placebo-Controlled Study in Generalized Epilepsy

This double-blind, placebo-controlled crossover study evaluated transcranial magnetic stimulation (TMS) combined with electromyography and electroencephalography as biomarkers for assessing anti-seizure medication effects in 26 patients with generalized epilepsy. Levetiracetam significantly reduced cortical excitability markers (reduced motor-evoked potentials, enhanced intracortical inhibition, increased gamma/beta power), suggesting TMS-derived measures are valid translational biomarkers for early-phase drug development and treatment-resistant epilepsy.

StudiuEpilepsieÎncredere bună19.06.2026

Glymphatic system dysfunction in epilepsy: mechanisms and clinical evidence

The glymphatic system, a cerebrospinal fluid-based waste clearance pathway, may be impaired in epilepsy due to seizure-induced neuroinflammation and blood-brain barrier disruption, potentially contributing to seizure generation. DTI-ALPS imaging demonstrates reduced glymphatic function in epilepsy patients, with greater impairment correlating with age, disease duration, cognitive decline, and drug resistance.

StudiuEpilepsieÎncredere bună19.06.2026

Privacy-Preserving Federated Spatiotemporal Dynamic Graph Neural Network Framework for Epileptic Seizure Prediction

This paper proposes a federated learning framework for epilepsy seizure prediction that addresses privacy concerns and data-sharing constraints in clinical environments. The approach uses dynamic graph neural networks to model the time-varying topological characteristics of EEG signals, improving upon traditional static modeling methods that fail to capture high-order nonlinear correlations in brain functional networks.

StudiuEpilepsieÎncredere bună19.06.2026

Combined TRPM4/NMDA Receptor and Extrasynaptic NMDA Inhibition as Therapeutic Target for Seizure Suppression and Cognitive Improvement in Epilepsy

This preclinical study investigates the effects of various NMDA receptor modulators and channel inhibitors on seizure frequency and cognitive function in a genetic rat epilepsy model with comorbid cognitive impairment. Combination treatments, particularly memantine with FP802, showed promise in reducing seizures while improving mood-related behaviors and restoring abnormal glutamate/glutamatergic signaling patterns.

StudiuEpilepsieÎncredere bună19.06.2026

Pregnancy and Epileptic Seizures in the Emergency Department: A Retrospective Clinical Analysis

This retrospective study of 48 pregnant women presenting to the emergency department with generalized tonic-clonic seizures found that 69% had pre-existing epilepsy and 58% were on antiseizure medications, with levetiracetam being most common. Management addressed diagnostic complexity between epilepsy and eclampsia, with seizure control achieved through appropriate medications including magnesium sulfate in suspected eclampsia cases.

StudiuEpilepsieÎncredere înaltă19.06.2026

EEG Findings in Emergency Department Patients with Altered Mental Status

Retrospective study of 112 emergency department patients presenting with altered mental status who underwent EEG, finding that 8.9% had seizures on EEG, with 60% being subclinical (lacking clinical manifestations). The study demonstrates that nonconvulsive status epilepticus (NCSE) is an important but often unrecognized cause of altered mental status requiring emergent EEG evaluation.

StudiuEpilepsieÎncredere înaltă19.06.2026

Phase 2A Trial of ES-481, a Novel AMPA Receptor Antagonist, for Drug-Resistant Epilepsy

This double-blind, randomized, placebo-controlled trial evaluated ES-481, a selective TARP-γ8-dependent AMPA receptor antagonist, as an add-on therapy in 22 adults with drug-resistant epilepsy across Australian epilepsy centers. At the highest dose (75 mg twice daily), ES-481 showed 80% improvement in seizure frequency compared to 49% with placebo, with safety and tolerability assessments conducted alongside pharmacokinetic analysis.

StudiuEpilepsieÎncredere bună19.06.2026

Systematic Review of Explainable Artificial Intelligence for Epileptic Seizure Onset Early Warning: Towards Responsible Artificial Intelligence

This systematic review examines explainable AI applications for early warning of epileptic seizures, evaluating 26 studies published 2019-2024 against responsible AI principles. The analysis identifies transparency and explainability as high-risk domains, highlighting current challenges in ensuring safety and accountability of AI-based seizure prediction systems.

StudiuEpilepsieÎncredere înaltă19.06.2026

Anti-Seizure Medication Risk Profiles in Childbearing-Age Women with Epilepsy in a Taenia solium Endemic Region

This population-based study examined anti-seizure medication prescribing patterns among 685 women of childbearing age with epilepsy in Peru, where neurocysticercosis is highly prevalent. The research found that most patients received medications with possible or inadequate teratogenic data, while 12.8% received established high-risk medications like valproic acid, highlighting treatment challenges in resource-limited endemic regions.